ea0034p157 | Cytokines and growth factors | SFEBES2014
Dunford Louise
, Gardner David
, Duckworth Benjamin
, O'Sullivan Saoirse
, Devonald Mark
Background: Acute kidney injury (AKI) is common and serious, with no specific treatment. AKI may increase the risk of dysfunction in organs other than the kidney, further increasing the morbidity associated with AKI. The mechanisms of organ cross-talk after AKI are unclear. Small animal models have suggested that infiltration of inflammatory cytokines into extra-renal organs leads to cellular extravasation, oedema and further injury. In this study we used a large animal model ...